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 您现在位置: -医药产业 >> 辅料添加剂 >> 甜味剂 >> 浏览辅料添加剂

欧盟重新评估赤藓糖醇作为食品添加剂的安全性

作者:zhoujian   来源:转载    点击数:0    更新时间:2023/12/26 17:45:12

[关键字]: 赤藓糖醇

讯:

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   2023年12月20日,据欧盟食品安全局(EFSA)消息,欧盟食品添加剂和调味剂小组(FAF)重新评估了赤藓糖醇(erythritol)(E 968)作为食品添加剂的安全性。
 
  部分原文报道如下:
  This opinion addresses the re-evaluation of erythritol (E?968) as food additive an application for its exemption from the laxative warning label requirement as established under Regulation (EU) No 1169/2011. Erythritol is a polyol obtained by fermentation with Moniliella pollinis BC or Moniliella megachiliensis KW3-6, followed by purifications drying. Erythritol is readily dose-dependently absorbed in humans can be metabolised to erythronate to a small extent. Erythritol is then excreted unchanged in the urine. It does not raise concerns regarding genotoxicity. The dataset evaluated consisted of human interventional studies. The Panel considered that erythritol has the potential to cause diarrhoea in humans, which was considered adverse because its potential association with electrolyte water imbalance. The lower bound of the range of no observed adverse effect levels (NOAELs) for diarrhoea of 0.5 g/kg body weight (bw) was identified as reference point. The Panel considered appropriate to set a numerical acceptable daily intake (ADI) at the level of the reference point. An ADI of 0.5 g/kg bw per day was considered by the Panel to be protective for the immediate laxative effect as well as potential chronic effects, secondary to diarrhoea. The highest mean 95th percentile chronic exposure was in children (742 mg/kg bw per day) adolescents (1532 mg/kg bw per day). Acute exposure was maximally 3531 mg/kg bw per meal for children at the 99th percentile. Overall, the Panel considered both dietary exposure assessments an overestimation. The Panel concluded that the exposure estimates for both acute chronic dietary exposure to erythritol (E 968) were above the ADI, indicating that individuals with high intake may be at risk of experiencing adverse effects after single repeated exposure. Concerning the new application, the Panel concluded that the available data do not support the proposal for exemption.

<%Else%> 欧盟重新评估赤藓糖醇作为食品添加剂的安全性 <%End If%>
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